Boss Gary Peters, who made some bold selections of the day, is hoping that Town can transfer their home form to that of their travels.
Peters told ShrewsWeb: "I'm concerned with the fact that this club has such a good record at home but such a poor record away from home, I want to change that mentality of how we can go away and be such easy targets."
Cheltenham are currently at the bottom of the League Two form table, having lost five of their last six games, but Peters is expecting a tough work-out.
"Cheltenham are mid-table and I doubt they think they will make the play-offs but it doesn't mean it'll be easy for us, they have a good manager in John Ward, he knows that he's doing."
Peters looks set to keep faith with the young players who succeeded against Oxford, with Joe Hart likely to continue in goal, with Neil Ashton and possible Dave Edwards in midfield.
The teams met earlier in the season, when Town were under the tenure of Jimmy Quinn. The Meadow men recorded a 2-0 win with goals from Luke Rodgers and the now departed Ryan Lowe.